(2-Azido-1,1-difluoroethyl)benzene → 2,2-Difluoro-2-phenylethylamine

HRID 911571ノート

反応式

HRID 911571 の反応式
[N:1]([CH2:4][C:5]([C:8]1[CH:13]=[CH:12][CH:11]=[CH:10][CH:9]=1)([F:7])[F:6])=[N+]=[N-]>CCOC(C)=O.[Pd]>[F:6][C:5]([F:7])([C:8]1[CH:9]=[CH:10][CH:11]=[CH:12][CH:13]=1)[CH2:4][NH2:1]

参加物

4

反応物 1

HCID 57656188(2-Azido-1,1-difluoroethyl)benzene

生成物 1

HCID 126355292,2-Difluoro-2-phenylethylamine収率 98.3%

試薬・触媒・溶媒 2

HCID 23938Palladium触媒HCID 8857Ethyl Acetate溶媒

実験手順

Dissolve (2-azido-1,1-difluoro-ethyl)-benzene (475 mg, 2.59 mmol) in EtOAc (30 mL). Add 10% Pd/C and submit the mixture to hydrogenation under atmospheric pressure (balloon) for 1 h. Filter the catalyst through Celite® and concentrate the filtrate in vacuo to provide the title compound as an oil (400 mg, 98%) that was used without any further purification.

後処理

  1. customfor 1 h
  2. filtrationFilter the catalyst through Celite®
  3. concentrationconcentrate the filtrate in vacuo

出典と根拠

ORDレコード
ord-f178a31c1b314fef81337af121289a79
出典データセット
uspto-grants-2011_09
特許番号
US08022062B2

反応ノート

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