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Acetic Anhydride → 1-(4-((2-(3-Phenoxy-5-(thieno[3,2-b]pyridin-7-ylthio)pyridin-2-ylamino)thiazol-4-yl)methyl)piperidin-1-yl)ethanone

HRID 911941
ノート
印刷プレビュー

反応式

HRID 911941 の反応式
[C:1](OC(=O)C)(=[O:3])[CH3:2].Cl.Cl.[O:10]([C:17]1[C:18]([NH:33][C:34]2[S:35][CH:36]=[C:37]([CH2:39][CH:40]3[CH2:45][CH2:44][NH:43][CH2:42][CH2:41]3)[N:38]=2)=[N:19][CH:20]=[C:21]([S:23][C:24]2[CH:29]=[CH:28][N:27]=[C:26]3[CH:30]=[CH:31][S:32][C:25]=23)[CH:22]=1)[C:11]1[CH:16]=[CH:15][CH:14]=[CH:13][CH:12]=1.C(N(CC)CC)C>C1COCC1>[O:10]([C:17]1[C:18]([NH:33][C:34]2[S:35][CH:36]=[C:37]([CH2:39][CH:40]3[CH2:45][CH2:44][N:43]([C:1](=[O:3])[CH3:2])[CH2:42][CH2:41]3)[N:38]=2)=[N:19][CH:20]=[C:21]([S:23][C:24]2[CH:29]=[CH:28][N:27]=[C:26]3[CH:30]=[CH:31][S:32][C:25]=23)[CH:22]=1)[C:11]1[CH:16]=[CH:15][CH:14]=[CH:13][CH:12]=1
参加物実験手順後処理出典と根拠反応ノート

参加物

5

反応物 3

HCID 7918Acetic AnhydrideHCID 8471TriethylamineHCID 866315353-phenoxy-N-(4-(piperidin-4-ylmethyl)thiazol-2-yl)-5-(thieno[3,2-b]pyridin-7-ylthio)pyridin-2-amine dihydrochloride

生成物 1

HCID 577429321-(4-((2-(3-Phenoxy-5-(thieno[3,2-b]pyridin-7-ylthio)pyridin-2-ylamino)thiazol-4-yl)methyl)piperidin-1-yl)ethanone収率 91.2%

試薬・触媒・溶媒 1

HCID 8028
Tetrahydrofuran
溶媒

実験手順

Added acetic anhydride (0.0169 g, 0.165 mmol) to a mixture of 3-phenoxy-N-(4-(piperidin-4-ylmethyl)thiazol-2-yl)-5-(thieno[3,2-b]pyridin-7-ylthio)pyridin-2-amine dihydrochloride (0.100 g, 0.165 mmol), triethylamine (0.0837 g, 0.827 mmol), and THF (5 mL) at 0° C. Warmed to ambient temperature and stirred for 4 hours. Partitioned between ethyl acetate and 2N NaOH, washed with water, brine, dried, and concentrated. The residue was dissolved in dichloromethane (2 mL) and 1N HCl in ether was added. Diluted in hexanes, and concentrated, added hexanes again and concentrated to afford the title compound ((Mixture of rotamers; 0.092 g, 91.2% yield) as a light yellow powder: 1H NMR (d6-DMSO) δ 8.65 (d, 1H); 8.47 (d, 1H), 8.46 (s, 1H), 7.77 (d, 1H), 7.41 (s, 1H), 7.41 (d, 2H), 7.15-7.20 (m, 4H), 6.84 (s, 1H), 0.95-4.36 (m, 1H), 1.97 (s, 3H).

後処理

  1. customPartitioned between ethyl acetate and 2N NaOH
  2. washwashed with water, brine
  3. customdried
  4. concentrationconcentrated
  5. dissolutionThe residue was dissolved in dichloromethane (2 mL)
  6. addition1N HCl in ether was added
  7. additionDiluted in hexanes
  8. concentrationconcentrated
  9. additionadded hexanes again
  10. concentrationconcentrated

出典と根拠

ORDレコード
ord-ce63e42686d7451a9f8934dee2b25348
出典データセット
uspto-grants-2011_09
DOI
10.6084/m9.figshare.5104873.v1
特許番号
US08022223B2

反応ノート

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