2'-(Trifluoromethoxy)acetophenone → 1-(2-(Trifluoromethoxy)phenyl)ethanol
反応式
[F:1][C:2]([F:14])([F:13])[O:3][C:4]1[CH:9]=[CH:8][CH:7]=[CH:6][C:5]=1[C:10](=[O:12])[CH3:11].[H-].[H-].[H-].[H-].[Li+].[Al+3]>C1COCC1.O>[F:1][C:2]([F:13])([F:14])[O:3][C:4]1[CH:9]=[CH:8][CH:7]=[CH:6][C:5]=1[CH:10]([OH:12])[CH3:11]参加物
5
実験手順
To a solution of 1-(2-Trifluoromethoxyphenyl)ethanone (1.00 g, 4.90 mmol) in THF (5 mL) at 0° C. was added 1M LiAlH4 in THF (5.9 mL, 5.9 mmol), and the solution was allowed to warm to rt. A few drops of water were added to quench. The mixture was concentrated in vacuo, transferred to a separatory funnel, and extracted using DCM and sat. aq. Rochelle salt. The organic layer was concentrated in vacuo to afford the title compound as a clear oil.
後処理
- customto quench
- concentrationThe mixture was concentrated in vacuo
- customtransferred to a separatory funnel
- extractionextracted
- concentrationThe organic layer was concentrated in vacuo
出典と根拠
- ORDレコード
- ord-27d8b26c923143d0abde8c82455186f2
- 出典データセット
- uspto-grants-2011_09
- 特許番号
- US08022206B2
反応ノート
読み込み中…