Sodium borohydride → 1-(2-Chloronaphthalen-1-yl)ethanol

HRID 912028ノート

反応式

HRID 912028 の反応式
[Cl:1][C:2]1[CH:11]=[CH:10][C:9]2[C:4](=[CH:5][CH:6]=[CH:7][CH:8]=2)[C:3]=1[C:12](=[O:14])[CH3:13].[BH4-].[Na+]>CCO>[Cl:1][C:2]1[CH:11]=[CH:10][C:9]2[C:4](=[CH:5][CH:6]=[CH:7][CH:8]=2)[C:3]=1[CH:12]([OH:14])[CH3:13]

参加物

4

反応物 2

HCID 4311764Sodium borohydrideHCID 674028271-(2-Chloro-1-naphthalenyl)ethanone

生成物 1

HCID 2307821-(2-Chloronaphthalen-1-yl)ethanol

試薬・触媒・溶媒 1

HCID 702Ethanol溶媒

実験手順

To an EtOH (70 ml) solution of 1-(2-Chloronaphthalen-1-yl)-ethanone (3.98 mmol; prepared according to J. Org. Chem. 1946, 11, 163-169) was added sodium borohydride (232 mg, 6.09 mmol). The mixture was stirred at rt under an atmosphere of nitrogen for one hour. After that time, the mixture was quenched with saturated NH4Cl followed by water, extracted with EtOAc (3×50 ml). The extracts were washed with water (50 ml), brine (50 ml), and dried over MgSO4. After concentration in vacuo, a beige oil was obtained. It was purified by chromatography on silica gel (25 g) eluting with an EtOAc/hexane gradient to give the title compound as a colorless oil. 1H NMR (400 MHz, CDCl3): δ=1.44 (d, J=6.4 Hz, 3H), 2.33 (d, J=3.6 Hz, 1H), 5.97-6.06 (m, 1H), 7.39 (d, J=8.8 Hz, 1H), 7.45-7.58 (m, 2H), 7.67 (d, J=8.8 Hz, 1H), 7.81 (dd, J=1.6, 8.0 Hz, 1H), 8.75 (d, J=8.0 Hz, 1H). MS (ES+): 189.19/191.20 [MH+−H2O]. HPLC: tR=3.38 min (polar—5 min, ZQ3).

後処理

  1. customAfter that time, the mixture was quenched with saturated NH4Cl
  2. extractionextracted with EtOAc (3×50 ml)
  3. washThe extracts were washed with water (50 ml), brine (50 ml)
  4. dry with materialdried over MgSO4
  5. concentrationAfter concentration in vacuo
  6. customa beige oil was obtained
  7. customIt was purified by chromatography on silica gel (25 g)
  8. washeluting with an EtOAc/hexane gradient

出典と根拠

ORDレコード
ord-7927cdb8baa2479abe6d6b234548a440
出典データセット
uspto-grants-2011_09
特許番号
US08022206B2

反応ノート

読み込み中…