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3,3',5,5'-Tetraiodothyroformic acid → 3-[(5-chloro-1H-indol-3-yl)methyl]-2-thioxo-1,2,3,7-tetrahydro-6H-purin-6-one
関与物質
| 役割 | 名称 | HCID | 仕込み量 |
|---|---|---|---|
| 反応物 | 3,3',5,5'-Tetraiodothyroformic acid | HCID 6451352 | — |
| 反応物 | tert-butyl 5-chloro-3-[(6-oxo-2-thioxo-1,2,6,7-tetrahydro-3H-purin-3-yl)methyl]-1H-indole-1-carboxylate | HCID 86631122 | — |
| 溶媒 | Dichloromethane | HCID 6344 | — |
| 生成物 | 3-[(5-chloro-1H-indol-3-yl)methyl]-2-thioxo-1,2,3,7-tetrahydro-6H-purin-6-one | HCID 24855500 | 68% |
反応手順
A solution of tert-butyl 5-chloro-3-[(6-oxo-2-thioxo-1,2,6,7-tetrahydro-3H-purin-3-yl)methyl]-1H-indole-1-carboxylate (0.043 g, 0.10 mmol, obtained from Example 10(c)) in CH2Cl2:TFA 4:1 (2 mL) was stirred for 3.5 h and then evaporated. Purification of the crude product by preparative HPLC gave the title compound (0.022 g, 68%) as a solid.
情報源と証拠
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 特許番号 | US08026244B2 |
| 出典データセット | uspto-grants-2011_09 |
| ORD ID | ord-24220a6edfb24459b66750bd182258b7 |
| 出典メモ | uspto-grants-2011_09 |