2-Methylcarbamoyl-piperazine-1,4-dicarboxylic acid dibenzyl ester → N-Methylpiperazine-2-carboxamide
反応式
C(OC([N:11]1[CH2:16][CH2:15][N:14](C(OCC2C=CC=CC=2)=O)[CH2:13][CH:12]1[C:27](=[O:30])[NH:28][CH3:29])=O)C1C=CC=CC=1>C(O)C.[Pd]>[CH3:29][NH:28][C:27]([CH:12]1[CH2:13][NH:14][CH2:15][CH2:16][NH:11]1)=[O:30]参加物
4
実験手順
A suspension of 2-methylcarbamoyl-piperazine-1,4-dicarboxylic acid dibenzyl ester from step (b) above (1.64 g, 4.0 mmol) and 10% Pd/C (42 mg, 0.04 mmol, Aldrich) in ethanol (10 mL) was vigorously stirred under hydrogen atmosphere for 4 h at room temperature. The catalyst was filtered through Celite® pad and the filter cake was washed with EtOH. The filtrate was evaporated in vacuo to give the title compound, which was used in the next step without additional purification. MS (ESI, pos. ion) m/e: 144 (M+1).
後処理
- filtrationThe catalyst was filtered through Celite® pad
- washthe filter cake was washed with EtOH
- customThe filtrate was evaporated in vacuo
出典と根拠
- ORDレコード
- ord-15fae098254d4b699d2bdeba13d8ed2c
- 出典データセット
- uspto-grants-2011_09
- 特許番号
- US08026241B2
反応ノート
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