Methyl triflate → 5-Methoxy-4-azatricyclo[4.3.1.1,3,8]undec-4-ene

HRID 913050ノート

反応式

HRID 913050 の反応式
[CH:1]12[CH2:11][CH:6]3[CH2:7][CH:8]([CH2:10][CH:3]([NH:4][C:5]3=[O:12])[CH2:2]1)[CH2:9]2.O(C)S([C:17](F)(F)F)(=O)=O>C(Cl)Cl>[CH3:17][O:12][C:5]1[CH:6]2[CH2:11][CH:1]3[CH2:9][CH:8]([CH2:10][CH:3]([CH2:2]3)[N:4]=1)[CH2:7]2

参加物

4

反応物 2

HCID 9526Methyl triflateHCID 2866474-Azatricyclo[4.3.1.13,8]undecan-5-one

生成物 1

HCID 866090545-Methoxy-4-azatricyclo[4.3.1.1,3,8]undec-4-ene

試薬・触媒・溶媒 1

HCID 6344Dichloromethane溶媒

実験手順

To a solution of 4-azatricyclo[4.3.1.13,8]undecan-5-one 3-A (1.00 g, 6.05 mmol) in 10 mL methylene chloride was added methyl triflate (2.98 g, 3 eq) and the reaction was heated at reflux for 20 min, after which time all volatiles were removed under reduced pressure to afford crude 5-methoxy-4-azatricyclo[4.3.1.13,8]undec-4-ene 3-B which was used in the next step without further purification.

後処理

  1. temperaturethe reaction was heated
  2. temperatureat reflux for 20 min
  3. customafter which time all volatiles were removed under reduced pressure

出典と根拠

ORDレコード
ord-f4452dc3a9414858b90eaa30610000e8
出典データセット
uspto-grants-2011_09
特許番号
US08026264B2

反応ノート

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