HCID 86625622、化合物 → Stavudine

HRID 913265

反応式

HRID 913265 の反応式
[CH3:1][C:2]1[C:8](=[O:9])[NH:7][C:5](=[O:6])[N:4]([C@@H:10]2[O:14][C@H:13]([CH2:15][OH:16])[CH:12]=[CH:11]2)[CH:3]=1.CN1C(=O)N(C)CCC1>O>[C@@H:10]1([N:4]2[CH:3]=[C:2]([CH3:1])[C:8](=[O:9])[NH:7][C:5]2=[O:6])[O:14][C@H:13]([CH2:15][OH:16])[CH:12]=[CH:11]1

参加物

3

反応物 1

HCID 86625622HCID 86625622、化合物

生成物 1

HCID 18283Stavudine収率 66.82%

試薬・触媒・溶媒 1

HCID 962Water溶媒

反応条件

温度
2.5 °C

実験手順

Stavudine DMPU solvate (20 g, 0.057 mole) is dissolved in water (20 ml) at 55° C. and the solution is allowed cooling on its own for an hour to crystallize. The mixture is further cooled on 0-5° C. for 2 hrs. The precipitated product is filtered, washed with acetone and dried to give 8.5 g (66.82%) of pure white crystalline Stavudine. HPLC results are given in Table-2

後処理

  1. temperaturethe solution is allowed cooling on its own for an hour
  2. customto crystallize
  3. filtrationThe precipitated product is filtered
  4. washwashed with acetone
  5. customdried

出典と根拠

ORDレコード
ord-c22b27eb05fb4b52934752f5d42be106
出典データセット
uspto-grants-2011_09
特許番号
US08026356B2

関連ノート

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