1-Butanol → N-(3-fluorophenyl)-6-iodo-4-pyrimidinamine
反応式
I[C:2]1[CH:7]=[C:6]([I:8])[N:5]=[CH:4][N:3]=1.[F:9][C:10]1[CH:11]=[C:12]([CH:14]=[CH:15][CH:16]=1)[NH2:13].C(N(CC)C(C)C)(C)C.C(O)CCC>O>[F:9][C:10]1[CH:11]=[C:12]([NH:13][C:2]2[CH:7]=[C:6]([I:8])[N:5]=[CH:4][N:3]=2)[CH:14]=[CH:15][CH:16]=1参加物
6
反応条件
- 温度
- 120 °C
実験手順
A mixture of 4,6-diiodopyrimidine (1.0 g, 3.01 mmol), 3-fluoroaniline (290 μL, 3.01 mmol), N,N-diisopropylethylamine (782 μL, 4.52 mmol) and n-butanol (3 mL) under nitrogen was stirred at 120° C. for 4 h. After cooling to room temperature, the solution was poured into water and extracted with ethyl acetate. The organic layer was washed once with 1 N hydrochloric acid, followed by brine, dried and concentrated to yield 0.68 g of title compound.
後処理
- temperatureAfter cooling to room temperature
- extractionextracted with ethyl acetate
- washThe organic layer was washed once with 1 N hydrochloric acid
- customdried
- concentrationconcentrated
出典と根拠
- ORDレコード
- ord-95c9daeeea0347cba96e69ac48d42b30
- 出典データセット
- uspto-grants-2011_09
- 特許番号
- US08026359B2
反応ノート
読み込み中…