Water → N-(4-Bromo-3-chloro-2-methylphenyl)acetamide

HRID 913592

反応式

HRID 913592 の反応式
[Cl:1][C:2]1[C:3]([CH3:12])=[C:4]([NH:8][C:9](=[O:11])[CH3:10])[CH:5]=[CH:6][CH:7]=1.[Br:13]Br.O>C(O)(=O)C>[Br:13][C:7]1[CH:6]=[CH:5][C:4]([NH:8][C:9](=[O:11])[CH3:10])=[C:3]([CH3:12])[C:2]=1[Cl:1]

参加物

5

反応物 3

HCID 962WaterHCID 24408BromineHCID 81969N-(3-chloro-2-methylphenyl)acetamide

生成物 1

HCID 86376N-(4-Bromo-3-chloro-2-methylphenyl)acetamide収率 99.5%

試薬・触媒・溶媒 1

HCID 176Acetic Acid溶媒

反応条件

温度
10 °C

実験手順

A suspension of N-(3-chloro-2-methylphenyl)acetamide (11.12 g, 60.63 mmol) in acetic acid (80 mL) was cooled to ca. 10° C. and then treated with bromine (9.28 mL, 181.11 mmol). The resulting mixture was stirred at rt for 2 h. The cooled solution was then poured into water (100 mL). The resulting solid was collected via filtration and rinsed with water. Thorough drying afforded 15.83 g of a pale yellow solid: MS (APCl) m/z 264 (M+2 isotope).

後処理

  1. filtrationThe resulting solid was collected via filtration
  2. washrinsed with water
  3. customThorough drying

出典と根拠

ORDレコード
ord-65dac5ab16ee462f9774f2d7d1a6a4b8
出典データセット
uspto-grants-2011_09
特許番号
US08026262B2

関連ノート

読み込み中…