Trifluoroacetic acid → 2-{[4-(2-{[3-(4-chlorophenyl)-1-methyl-1H-pyrazol-5-yl]amino}ethyl)-1,3-thiazol-2-yl]thio}-2-methylpropionic acid

HRID 914397

反応式

HRID 914397 の反応式
C([O:5][C:6](=[O:20])[C:7]([S:10][C:11]1[S:12][CH:13]=[C:14]([CH2:16][C:17](O)=O)[N:15]=1)([CH3:9])[CH3:8])(C)(C)C.[Cl:21][C:22]1[CH:27]=[CH:26][C:25]([C:28]2[CH:32]=[C:31]([NH2:33])[N:30]([CH3:34])[N:29]=2)=[CH:24][CH:23]=1.FC(F)(F)C(O)=O>ClCCl>[Cl:21][C:22]1[CH:23]=[CH:24][C:25]([C:28]2[CH:32]=[C:31]([NH:33][CH2:17][CH2:16][C:14]3[N:15]=[C:11]([S:10][C:7]([CH3:8])([CH3:9])[C:6]([OH:5])=[O:20])[S:12][CH:13]=3)[N:30]([CH3:34])[N:29]=2)=[CH:26][CH:27]=1

参加物

5

反応物 3

HCID 6422Trifluoroacetic acidHCID 27353043-(4-Chlorophenyl)-1-Methyl-1H-Pyrazol-5-AmineHCID 59759443HCID 59759443、化合物

生成物 1

HCID 597588902-{[4-(2-{[3-(4-chlorophenyl)-1-methyl-1H-pyrazol-5-yl]amino}ethyl)-1,3-thiazol-2-yl]thio}-2-methylpropionic acid

試薬・触媒・溶媒 1

HCID 6344Dichloromethane溶媒

実験手順

The compound obtained using {2-[(2-tert-butoxy-1,1-dimethyl-2-oxoethyl)thio]-1,3-thiazol-4-yl}acetic acid synthesized in Example 3 and 3-(4-chlorophenyl)-1-methyl-1H-pyrazole-5-amine as starting materials and by operations similar to those of Example 242-1 and Example 242-2 was treated with dichloromethane and trifluoroacetic acid, and the mixture was stirred at room temperature for 12 hr. The reaction mixture was concentrated under reduced pressure, and the residue was purified by silica gel chromatography (elution solvent; chloroform:methanol=20:1) to give the title compound.

後処理

  1. customThe compound obtained
  2. concentrationThe reaction mixture was concentrated under reduced pressure
  3. customthe residue was purified by silica gel chromatography (elution solvent; chloroform:methanol=20:1)

出典と根拠

ORDレコード
ord-c80070c6982d4d75992c1e9493fe8b4b
出典データセット
uspto-grants-2011_09
特許番号
US08026370B2

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