Trifluoroacetic acid → 2-[(4-{3-[(3-Cyanopyridin-2-yl)(heptyl)amino]propyl}-1,3-thiazol-2-yl)thio]-2-methylpropionic acid trifluoroacetate

HRID 914430ノート

反応式

HRID 914430 の反応式
C([O:5][C:6](=[O:20])[C:7]([S:10][C:11]1[S:12][CH:13]=[C:14]([CH2:16][CH2:17][CH2:18][NH2:19])[N:15]=1)([CH3:9])[CH3:8])(C)(C)C.Cl[C:22]1[N:29]=[CH:28][CH:27]=[CH:26][C:23]=1[C:24]#[N:25].[F:30][C:31]([F:36])([F:35])[C:32]([OH:34])=[O:33]>ClCCl>[F:30][C:31]([F:36])([F:35])[C:32]([OH:34])=[O:33].[C:24]([C:23]1[C:22]([N:19]([CH2:13][CH2:14][CH2:16][CH2:17][CH2:18][CH2:31][CH3:32])[CH2:18][CH2:17][CH2:16][C:14]2[N:15]=[C:11]([S:10][C:7]([CH3:8])([CH3:9])[C:6]([OH:5])=[O:20])[S:12][CH:13]=2)=[N:29][CH:28]=[CH:27][CH:26]=1)#[N:25]

参加物

5

反応物 3

HCID 6422Trifluoroacetic acidHCID 810792-ChloronicotinonitrileHCID 597590072-{[4-(3-Aminopropyl)-1,3-thiazol-2-yl]thio}-2-methylpropionic acid tert-butyl ester

生成物 1

HCID 673986292-[(4-{3-[(3-Cyanopyridin-2-yl)(heptyl)amino]propyl}-1,3-thiazol-2-yl)thio]-2-methylpropionic acid trifluoroacetate

試薬・触媒・溶媒 1

HCID 6344Dichloromethane溶媒

実験手順

A compound obtained using 2-{[4-(3-aminopropyl)-1,3-thiazol-2-yl]thio}-2-methylpropionic acid tert-butyl ester synthesized in Example 33 and 2-chloronicotinonitrile as starting materials and by operations similar to those of Example 265-1 and Example 265-2 was treated with dichloromethane and trifluoroacetic acid, and the mixture was stirred at room temperature for 12 hr. The reaction solution was concentrated under reduced pressure, and the residue was purified by silica gel chromatography (elution solvent; chloroform:methanol=50:1) to give the title compound.

後処理

  1. customA compound obtained
  2. concentrationThe reaction solution was concentrated under reduced pressure
  3. customthe residue was purified by silica gel chromatography (elution solvent; chloroform:methanol=50:1)

出典と根拠

ORDレコード
ord-92e1ef0f12aa4359b6fc22c94be92be3
出典データセット
uspto-grants-2011_09
特許番号
US08026370B2

反応ノート

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