4-Methyl-1-pentanol → HCID 67400871、化合物

HRID 914464

反応式

HRID 914464 の反応式
I[CH2:2][CH2:3][CH2:4][CH:5]([CH3:7])[CH3:6].C([O:12][C:13](=[O:34])[C:14]([S:17][C:18]1[S:19][CH:20]=[C:21]([CH2:23][CH2:24][NH:25][C:26]2[N:31]=[CH:30][C:29]([CH2:32][CH3:33])=[CH:28][N:27]=2)[N:22]=1)([CH3:16])[CH3:15])(C)(C)C.CC(C)CCCO.[BrH:42].C(O)(=O)C>C(OCC)C>[BrH:42].[CH2:32]([C:29]1[CH:28]=[N:27][C:26]([N:25]([CH2:2][CH2:3][CH2:4][CH:5]([CH3:7])[CH3:6])[CH2:24][CH2:23][C:21]2[N:22]=[C:18]([S:17][C:14]([CH3:15])([CH3:16])[C:13]([OH:34])=[O:12])[S:19][CH:20]=2)=[N:31][CH:30]=1)[CH3:33]

参加物

6

反応物 4

HCID 122964-Methyl-1-pentanolHCID 5275811-Iodo-4-methylpentaneHCID 21893785Acetic Acid Mixture with Hydrobromic AcidHCID 597588712-[(4-{2-[(5-Ethylpyrimidin-2-yl)amino]ethyl}-1,3-thiazol-2-yl)thio]-2-methylpropionic acid tert-butyl ester

生成物 1

HCID 67400871HCID 67400871、化合物

試薬・触媒・溶媒 1

HCID 3283Diethyl Ether溶媒

実験手順

A compound obtained using 1-iodo-4-methylpentane, which is synthesized using 2-[(4-{2-[(5-ethylpyrimidin-2-yl)amino]ethyl}-1,3-thiazol-2-yl)thio]-2-methylpropionic acid tert-butyl ester synthesized in Example 265-1 and 4-methylpentanol as starting materials and in reference to non-patent reference [Tetrahedron, 38, 11461 (1998)], and by an operation similar to that of Example 326, was dissolved in diethyl ether, and reacted with 30% hydrobromic acid-acetic acid to give the title compound.

後処理

  1. customA compound obtained
  2. customis synthesized

出典と根拠

ORDレコード
ord-0c832d8449ba48bfa70bc97c3d7c71aa
出典データセット
uspto-grants-2011_09
特許番号
US08026370B2

関連ノート

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