Methanol → HCID 67399122、化合物
反応式
[NH:1]([C:8](=O)[CH2:9][C:10]1[N:11]=[C:12]([S:15][C:16]([CH3:21])([CH3:20])[C:17]([OH:19])=[O:18])[S:13][CH:14]=1)[C:2]1[CH:7]=[CH:6][CH:5]=[CH:4][CH:3]=1.CO>O1CCCC1>[NH:1]([CH2:8][CH2:9][C:10]1[N:11]=[C:12]([S:15][C:16]([CH3:21])([CH3:20])[C:17]([OH:19])=[O:18])[S:13][CH:14]=1)[C:2]1[CH:7]=[CH:6][CH:5]=[CH:4][CH:3]=1参加物
4
実験手順
To a suspension of 2-{[4-(2-anilino-2-oxoethyl)-1,3-thiazol-2-yl]thio}-2-methylpropionic acid resin (2.9 g) obtained in Example 488-1 in tetrahydrofuran (30 mL) was added 1 mol/L borane-tetrahydrofuran complex (24 ml), and the mixture was stirred at room temperature overnight. Methanol was gradually added to the reaction mixture, and the mixture was stirred at room temperature overnight. The resin was collected by filtration, washed three times with methanol, and vacuum dried to give the title pale-brown resin (2.4 g).