5-Bromo-2-nitropyridine → HCID 16748110、化合物

反応式

Br[C:2]1[CH:3]=[CH:4][C:5]([N+:8]([O-:10])=[O:9])=[N:6][CH:7]=1.[C@H:11]12[CH2:17][C@H:14]([NH:15][CH2:16]1)[CH2:13][N:12]2[C:18]([O:20][C:21]([CH3:24])([CH3:23])[CH3:22])=[O:19]>>[N+:8]([C:5]1[N:6]=[CH:7][C:2]([N:15]2[CH2:16][C@@H:11]3[CH2:17][C@H:14]2[CH2:13][N:12]3[C:18]([O:20][C:21]([CH3:24])([CH3:23])[CH3:22])=[O:19])=[CH:3][CH:4]=1)([O-:10])=[O:9]

参加物

反応物 2

HCID 8176205-Bromo-2-nitropyridine

HCID 11521263(1S,4S)-2-Boc-2,5-diazabicyclo[2.2.1]heptane

生成物 1

HCID 16748110HCID 16748110、化合物

実験手順

5-Bromo-2-nitropyridine, prepared as described in (J. Am. Chem. Soc., (1945) 67, 668), and tert-butyl (1S,4S)-2,5-diazabicyclo[2.2.1]heptane-2-carboxylate, prepared as described in (J. Med. Chem., (1988) 31, 1598-1611), were coupled according to the procedure of Example 2A to provide the title compound.

後処理

customprepared

出典と根拠

ORDレコード: ord-965b885d41d540a4bdcf38ea63716d96
出典データセット: uspto-grants-2007_09
DOI: 10.6084/m9.figshare.5104873.v1
特許番号: US07265115B2

反応ノート

読み込み中…

参加物