Sodium Hydroxide → HCID 69333347、化合物
反応式
[NH2:1][C:2]1[C:3]([C:25](N)=[O:26])=[N:4][C:5]([C:15]2[CH:20]=[CH:19][C:18](=[O:21])[N:17]([CH:22]([CH3:24])[CH3:23])[N:16]=2)=[C:6]([C:8]2[CH:13]=[CH:12][CH:11]=[CH:10][C:9]=2[Br:14])[N:7]=1.[OH-:28].[Na+]>CCO>[NH2:1][C:2]1[C:3]([C:25]([OH:28])=[O:26])=[N:4][C:5]([C:15]2[CH:20]=[CH:19][C:18](=[O:21])[N:17]([CH:22]([CH3:24])[CH3:23])[N:16]=2)=[C:6]([C:8]2[CH:13]=[CH:12][CH:11]=[CH:10][C:9]=2[Br:14])[N:7]=1参加物
4
実験手順
A solution of 3-amino-5-(2-bromophenyl)-6-(1-isopropyl-6-oxo-1,6-dihydro-3-pyridazinyl)-2-pyrazinecarboxamide (695 mg) in a mixture of 5N aq. NaOH (4 ml) and EtOH (4 ml) was refluxed for 4 hours. After removal of EtOH by evaporation, the mixture was adjusted to pH 4 with 1N HCl to give a precipitate. The precipitate was collected by filtration and dried under reduced pressure to give 3-amino-5-(2-bromophenyl)-6-(1-isopropyl-6-oxo-1,6-dihydro-3-pyridazinyl)-2-pyrazinecarboxylic acid (664 mg).