Methanol → Methyl 2-amino-4,4-dimethylpentanoate

HRID 915199ノート

反応式

HRID 915199 の反応式
[NH2:1][CH:2]([CH2:6][C:7]([CH3:10])([CH3:9])[CH3:8])[C:3]([OH:5])=[O:4].S(Cl)(Cl)=O.[CH3:15]O>>[CH3:15][O:4][C:3](=[O:5])[CH:2]([NH2:1])[CH2:6][C:7]([CH3:10])([CH3:9])[CH3:8]

参加物

4

反応物 3

HCID 887MethanolHCID 24386Thionyl ChlorideHCID 3516272-Amino-3-tert-butylpropionic acid

生成物 1

HCID 23000049Methyl 2-amino-4,4-dimethylpentanoate

実験手順

2-Amino-4,4-dimethyl-pentanoic acid (1.00 g, 6.84 mmol) was suspended in 50 mL of methanol and cooled in an ice bath. Thionyl chloride (1.82 g, 15.0 mmol) was added dropwise, at which time all the acid went into solution. The reaction was then removed from the ice bath and heated to reflux for 3.5 h. The reaction mixture was concentrated in vacuo and the resulting solid (1.10 g) was used in the next step without further purification. MS, m/z 159.9=M+1.

後処理

  1. temperaturecooled in an ice bath
  2. customThe reaction was then removed from the ice bath
  3. temperatureheated
  4. temperatureto reflux for 3.5 h
  5. concentrationThe reaction mixture was concentrated in vacuo
  6. customthe resulting solid (1.10 g) was used in the next step without further purification

出典と根拠

ORDレコード
ord-6fca94d43be24b1f931bf19ece4f82ae
出典データセット
uspto-grants-2007_09
特許番号
US07265132B2

反応ノート

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