Hydrochloric Acid → [2-Methyl-5-(4-trifluoromethyl-phenyl)-2H-pyrazol-3-yl]-acetic acid

HRID 915419ノート

反応式

HRID 915419 の反応式
[CH3:1][N:2]1[C:6]([CH2:7][C:8]#N)=[CH:5][C:4]([C:10]2[CH:15]=[CH:14][C:13]([C:16]([F:19])([F:18])[F:17])=[CH:12][CH:11]=2)=[N:3]1.[OH-:20].[Na+].[OH2:22].Cl>C(O)C>[CH3:1][N:2]1[C:6]([CH2:7][C:8]([OH:22])=[O:20])=[CH:5][C:4]([C:10]2[CH:15]=[CH:14][C:13]([C:16]([F:19])([F:18])[F:17])=[CH:12][CH:11]=2)=[N:3]1

参加物

6

反応物 4

HCID 313Hydrochloric AcidHCID 962WaterHCID 14798Sodium HydroxideHCID 69282787[2-Methyl-5-(4-trifluoromethyl-phenyl)-2H-pyrazol-3-yl]-acetonitrile

生成物 1

HCID 69282814[2-Methyl-5-(4-trifluoromethyl-phenyl)-2H-pyrazol-3-yl]-acetic acid

試薬・触媒・溶媒 1

HCID 702Ethanol溶媒

反応条件

温度
85 °C

実験手順

A mixture of [2-methyl-5-(4-trifluoromethyl-phenyl)-2H-pyrazol-3-yl]-acetonitrile (267 mg, 1 mmol), sodium hydroxide (403 mg, 10 mmol), water (4 ml) and ethanol (4 ml) was stirred vigorously at 85° C. for 14 h. The reaction mixture was poured onto crushed ice and aqueous HCl and extracted three times with ethyl acetate. The combined extracts were washed with water and brine, and dried over anhydrous sodium sulfate. Evaporation of the solvent under reduced pressure gave 286 mg (1 mmol, quant.) of the title compound as off-white crystals.

後処理

  1. additionThe reaction mixture was poured
  2. extractionextracted three times with ethyl acetate
  3. washThe combined extracts were washed with water and brine
  4. dry with materialdried over anhydrous sodium sulfate
  5. customEvaporation of the solvent under reduced pressure

出典と根拠

ORDレコード
ord-d4521e7eeee24741947b0ff19dddd062
出典データセット
uspto-grants-2007_09
特許番号
US07265149B2

反応ノート

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