Sodium Iodide → 5-iodomethyl-1-methyl-3-(4-trifluoromethyl-phenyl)-1H-pyrazole

HRID 915488ノート

反応式

HRID 915488 の反応式
Cl[CH2:2][C:3]1[N:7]([CH3:8])[N:6]=[C:5]([C:9]2[CH:14]=[CH:13][C:12]([C:15]([F:18])([F:17])[F:16])=[CH:11][CH:10]=2)[CH:4]=1.[I-:19].[Na+]>CC(C)=O>[I:19][CH2:2][C:3]1[N:7]([CH3:8])[N:6]=[C:5]([C:9]2[CH:14]=[CH:13][C:12]([C:15]([F:18])([F:17])[F:16])=[CH:11][CH:10]=2)[CH:4]=1

参加物

4

反応物 2

HCID 5238Sodium IodideHCID 210822245-chloromethyl-1-methyl-3-(4-trifluoromethyl-phenyl)-1H-pyrazole

生成物 1

HCID 692828125-iodomethyl-1-methyl-3-(4-trifluoromethyl-phenyl)-1H-pyrazole

試薬・触媒・溶媒 1

HCID 180Acetone溶媒

実験手順

In analogy to the procedure described in example 20 a], 5-chloromethyl-1-methyl-3-(4-trifluoromethyl-phenyl)-1H-pyrazole (example 9 a]) was treated with sodium iodide in acetone to obtain 5-iodomethyl-1-methyl-3-(4-trifluoromethyl-phenyl)-1H-pyrazole as yellow solid which was used in the next step without further purification.

出典と根拠

ORDレコード
ord-6bf43f8f2469435dbe68adff14dfc595
出典データセット
uspto-grants-2007_09
特許番号
US07265149B2

反応ノート

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