Methanesulfonyl chloride → HCID 58958827、化合物

HRID 915525ノート

反応式

HRID 915525 の反応式
[N:1]1[CH:6]=[CH:5][CH:4]=[CH:3][C:2]=1[C:7]1[C:8]([C:15]2[C:24]3[C:19](=[CH:20][C:21]([O:25][CH2:26][CH2:27][OH:28])=[CH:22][CH:23]=3)[N:18]=[CH:17][CH:16]=2)=[C:9]2[CH2:14][CH2:13][CH2:12][N:10]2[N:11]=1.[CH3:29][S:30](Cl)(=[O:32])=[O:31]>N1C=CC=CC=1>[N:1]1[CH:6]=[CH:5][CH:4]=[CH:3][C:2]=1[C:7]1[C:8]([C:15]2[C:24]3[C:19](=[CH:20][C:21]([O:25][CH2:26][CH2:27][O:28][S:30]([CH3:29])(=[O:32])=[O:31])=[CH:22][CH:23]=3)[N:18]=[CH:17][CH:16]=2)=[C:9]2[CH2:14][CH2:13][CH2:12][N:10]2[N:11]=1

参加物

4

反応物 2

HCID 31297Methanesulfonyl chlorideHCID 17980603700874-74-4

生成物 1

HCID 58958827HCID 58958827、化合物収率 100%

試薬・触媒・溶媒 1

HCID 1049Pyridine溶媒

実験手順

Stir a solution of 2-[4-(2-pyridin-2-yl-5,6-dihydro-4H-pyrrolo[1,2-b]pyrazol-3-yl)-quinolin-7-yloxy]-ethanol (293 mg, 0.78 mmol) and methane sulfonyl chloride (68μL, 0.81 ml) in dried pyridine (5 mL) for 2 hours. Remove the pyridine in vacuo and recover the residue with chloroform. Wash the organic layer with saturated sodium bicarbonate and dry over sodium sulfate to give the desired subtitled intermediate as a white foam (425 mg, 100%). MS ES+ m/e 451.1 (M+1).

後処理

  1. customRemove the pyridine in vacuo
  2. customrecover the residue with chloroform
  3. washWash the organic layer with saturated sodium bicarbonate
  4. dry with materialdry over sodium sulfate

出典と根拠

ORDレコード
ord-0fa4932dcb4346b2a5ac59e971856b0e
出典データセット
uspto-grants-2007_09
特許番号
US07265225B2

反応ノート

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