Acetic Anhydride → Ethyl 2',4'-difluoro-4-acetyloxy-5-iodo-[1,1']biphenyl-3-carboxylate
反応式
[F:1][C:2]1[CH:7]=[C:6]([F:8])[CH:5]=[CH:4][C:3]=1[C:9]1[CH:19]=[C:13]([C:14]([O:16][CH2:17][CH3:18])=[O:15])[C:12]([OH:20])=[C:11]([I:21])[CH:10]=1.[C:22](OC(=O)C)(=[O:24])[CH3:23]>N1C=CC=CC=1>[F:1][C:2]1[CH:7]=[C:6]([F:8])[CH:5]=[CH:4][C:3]=1[C:9]1[CH:10]=[C:11]([I:21])[C:12]([O:20][C:22](=[O:24])[CH3:23])=[C:13]([C:14]([O:16][CH2:17][CH3:18])=[O:15])[CH:19]=1参加物
4
実験手順
A mixture of 500 mg (1.24 mmol) of ethyl 5-(2,4-difluorophenyl)-3-iodo-salicylate (Example 10) in 12 ml of pyridine and 3 ml of acetic anhydride was heated in a water bath for 20 min. The mixture was allowed to cool and poured over ice and the product was extracted with dichloromethane. After drying the organic phase and after evaporating the solvent at low pressure, the crude was recrystalized.