Hydrochloric Acid → 2-(2-Nitrovinyl)-5-phenylfuran

HRID 915648

反応式

HRID 915648 の反応式
[C:1]1([C:7]2[O:11][C:10]([CH:12]=O)=[CH:9][CH:8]=2)[CH:6]=[CH:5][CH:4]=[CH:3][CH:2]=1.CO.[OH-].[Na+].Cl.[N+:19]([CH3:22])([O-:21])=[O:20]>O>[N+:19]([CH:22]=[CH:12][C:10]1[O:11][C:7]([C:1]2[CH:6]=[CH:5][CH:4]=[CH:3][CH:2]=2)=[CH:8][CH:9]=1)([O-:21])=[O:20]

参加物

7

反応物 5

HCID 313Hydrochloric AcidHCID 887MethanolHCID 6375NitromethaneHCID 14798Sodium HydroxideHCID 27694205-Phenyl-2-furaldehyde

生成物 1

HCID 8012792-(2-Nitrovinyl)-5-phenylfuran

試薬・触媒・溶媒 1

HCID 962Water溶媒2 回

実験手順

Combine 5-phenylfuran-2-carbaldehyde (808 mg, 4.69 mmol), methanol (2.0 mL), and nitromethane (1.13 mL) and cool. Add a combination of 0.20 mL of 1M sodium hydroxide and 0.70 mL of water to the reaction. Stir the reaction for 15 minutes, dilute with water (5 mL), add 1.0 mL of concentrated hydrochloric acid, and stir for 20 additional hours. Extract the reaction with ethyl acetate, dry organics, filter and evaporate to yield 1.14 g of 2-(2-nitrovinyl)-5-phenylfuran as a brown oil which can be used without further purification. MH+ 216.0

後処理

  1. customto the reaction
  2. customthe reaction for 15 minutes
  3. stirringstir for 20 additional hours
  4. extractionExtract
  5. customthe reaction with ethyl acetate
  6. filtrationdry organics, filter
  7. customevaporate

出典と根拠

ORDレコード
ord-3025f83ffd4745d8b39fa8720adb10a3
出典データセット
uspto-grants-2007_09
特許番号
US07265246B2

関連ノート

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