Pyridine → 5-Chloro-2-(2,2-difluoroacetamido)benzenesulphonamide

HRID 915743

反応式

HRID 915743 の反応式
[NH2:1][C:2]1[CH:7]=[CH:6][C:5]([Cl:8])=[CH:4][C:3]=1[S:9]([NH2:12])(=[O:11])=[O:10].N1C=CC=CC=1.[F:19][CH:20]([F:24])[C:21](Cl)=[O:22]>O1CCOCC1>[Cl:8][C:5]1[CH:6]=[CH:7][C:2]([NH:1][C:21](=[O:22])[CH:20]([F:24])[F:19])=[C:3]([S:9]([NH2:12])(=[O:11])=[O:10])[CH:4]=1

参加物

5

反応物 3

HCID 1049PyridineHCID 27368902,2-Difluoroacetyl chlorideHCID 122955502-Amino-5-chlorobenzenesulphonamide

生成物 1

HCID 231042325-Chloro-2-(2,2-difluoroacetamido)benzenesulphonamide

試薬・触媒・溶媒 1

HCID 312751,4-Dioxane溶媒

実験手順

To 1 g of 2-amino-5-chlorobenzenesulphonamide (obtained in accordance with J. Chem. Soc. Perkin I 1979, 1043-1047) dissolved in 4 ml of dioxane there are added, in the cold state (+5° C.), 0.6 ml of pyridine and 0.6 ml of difluoroacetic acid chloride. The flask is hermetically closed immediately and subjected to vigorous stirring at ambient temperature for 10 minutes. The solvents are then removed under reduced pressure. The solid residue is taken up in water (12 ml), and the insoluble material is collected by filtration, washed with water and dried to yield the expected compound.

後処理

  1. customThe flask is hermetically closed immediately
  2. customThe solvents are then removed under reduced pressure
  3. filtrationthe insoluble material is collected by filtration
  4. washwashed with water
  5. customdried

出典と根拠

ORDレコード
ord-9d2c3e9d62a24924ad2245c0bdc30ea4
出典データセット
uspto-grants-2007_09
特許番号
US07268129B2

関連ノート

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