2-Methoxyethylamine → HCID 136333264、化合物

反応式

Br[C:2]1[CH:7]=[CH:6][C:5]([C:8]2[NH:9][C:10](=[O:24])[C:11]3[C:16]([CH:17]4[CH2:22][CH2:21][CH2:20][CH2:19][CH2:18]4)=[N:15][N:14]([CH3:23])[C:12]=3[N:13]=2)=[C:4]([O:25][CH2:26][CH3:27])[CH:3]=1.[CH3:28][O:29][CH2:30][CH2:31][NH2:32]>>[CH:17]1([C:16]2[C:11]3[C:10](=[O:24])[NH:9][C:8]([C:5]4[CH:6]=[CH:7][C:2]([NH:32][CH2:31][CH2:30][O:29][CH3:28])=[CH:3][C:4]=4[O:25][CH2:26][CH3:27])=[N:13][C:12]=3[N:14]([CH3:23])[N:15]=2)[CH2:22][CH2:21][CH2:20][CH2:19][CH2:18]1

参加物

反応物 2

HCID 80182-Methoxyethylamine

HCID 136005963HCID 136005963、化合物

生成物 1

HCID 136333264HCID 136333264、化合物収率 31%

実験手順

The same reaction procedure as in Example 27 was performed, except that the compound obtained in Example 85 was used in place of the compound obtained in Example 26, and 2-methoxyethylamine was used in place of N-methylpiperazine. In this manner, 46 mg (31%) of the captioned compound was obtained.

後処理

customThe same reaction procedure as in Example 27

出典と根拠

ORDレコード: ord-99e2e632b0e54b119fe682e5576fb42d
出典データセット: uspto-grants-2007_09
DOI: 10.6084/m9.figshare.5104873.v1
特許番号: US07268128B2

反応ノート

読み込み中…