(4-Pyrrolidin-1-ylnaphthalen-1-yl)phosphonic acid diethyl ester → HCID 11536812、化合物

HRID 916328ノート

反応式

HRID 916328 の反応式
[CH2:1]([O:3][P:4]([C:9]1[C:18]2[C:13](=[CH:14][CH:15]=[CH:16][CH:17]=2)[C:12]([N:19]2[CH2:23][CH2:22][CH2:21][CH2:20]2)=[CH:11][CH:10]=1)(=[O:8])[O:5]CC)[CH3:2]>N1CCCC1>[CH2:1]([O:3][P:4]([C:9]1[C:18]2[C:13](=[CH:14][CH:15]=[CH:16][CH:17]=2)[C:12]([N:19]2[CH2:23][CH2:22][CH2:21][CH2:20]2)=[CH:11][CH:10]=1)(=[O:5])[OH:8])[CH3:2]

参加物

3

反応物 1

HCID 11616946(4-Pyrrolidin-1-ylnaphthalen-1-yl)phosphonic acid diethyl ester

生成物 1

HCID 11536812HCID 11536812、化合物収率 59.6%

試薬・触媒・溶媒 1

HCID 31268Pyrrolidine溶媒

反応条件

温度
80 °C

実験手順

(4-Pyrrolidin-1-ylnaphthalen-1-yl)phosphonic acid diethyl ester 139MBT64-B (40 mg, 0.11 mmol) was dissolved in pyrrolidine (0.5 mL) and the mixture was heated to 80° C. for 20 hours. The mixture was concentrated and the crude product was purified by preparative TLC (0-10% methanol in dichloromethane) to give the title compound (20 mg, 55%) as a white solid.

後処理

  1. concentrationThe mixture was concentrated
  2. customthe crude product was purified by preparative TLC (0-10% methanol in dichloromethane)

出典と根拠

ORDレコード
ord-1c379ed0a0f24178a4089eb42a9d3e0e
出典データセット
uspto-grants-2007_09
特許番号
US07268232B2

反応ノート

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