Potassium Carbonate → 3-(4-Methylsulfonylpiperazin-1-yl)propan-1-ol
反応式
[CH3:1][S:2]([N:5]1[CH2:10][CH2:9][NH:8][CH2:7][CH2:6]1)(=[O:4])=[O:3].Br[CH2:12][CH2:13][CH2:14][OH:15].C(=O)([O-])[O-].[K+].[K+]>C(#N)C>[CH3:1][S:2]([N:5]1[CH2:10][CH2:9][N:8]([CH2:12][CH2:13][CH2:14][OH:15])[CH2:7][CH2:6]1)(=[O:4])=[O:3]参加物
5
反応条件
- 温度
- 70 °C
実験手順
A suspension of 1-(methylsulfonyl)piperazine (3 g, 18.3 mmol), 3-bromopropan-1-ol (3.3 g, 23.8 mmol) and potassium carbonate (3.28 g, 23.8 mmol) in acetonitrile (20 ml) was stirred at 70° C. for 4 hours. After cooling, the mixture was filtered and the filtrate was evaporated. The residue was purified by column chromatography eluting with increasingly polar mixtures of methanol and methylene chloride to give 3-(4-methylsulphonylpiperazin-1-yl)propan-1-ol (2.93 g, 72%).
後処理
- temperatureAfter cooling
- filtrationthe mixture was filtered
- customthe filtrate was evaporated
- customThe residue was purified by column chromatography
- washeluting
- temperaturewith increasingly polar mixtures of methanol and methylene chloride
出典と根拠
- ORDレコード
- ord-c83af9f3c96f4ad4b58fc956617639da
- 出典データセット
- uspto-grants-2007_09
- 特許番号
- US07268230B2
反応ノート
読み込み中…