Potassium Carbonate → 3-[4-(2-Fluoroethyl)piperazin-1-YL]propan-1-OL
反応式
Br[CH2:2][CH2:3][CH2:4][OH:5].C(=O)([O-])[O-].[K+].[K+].OC(C(F)(F)F)=O.OC(C(F)(F)F)=O.[F:26][CH2:27][CH2:28][N:29]1[CH2:34][CH2:33][NH:32][CH2:31][CH2:30]1>C(#N)C>[F:26][CH2:27][CH2:28][N:29]1[CH2:34][CH2:33][N:32]([CH2:2][CH2:3][CH2:4][OH:5])[CH2:31][CH2:30]1参加物
5
反応条件
- 温度
- 85 °C
実験手順
3-Bromopropan-1-ol (581 mg, 4.18 mmol) and potassium carbonate (2.88 g, 20.9 mmol) were added to a solution of 1-(2-fluoroethyl)-piperazine diTFA salt (1.5 g, 4.18 mmol) in acetonitrile (11 ml). The reaction mixture was stirred at 85° C. for 4 hours and then loaded directly onto a column and eluted with a mixture of methanol in methylene chloride (7/93) to give 3-[4-(2-fluoroethyl)piperazin-1-yl]propan-1-ol (721 mg, 91%).
後処理
- washeluted with a mixture of methanol in methylene chloride (7/93)
出典と根拠
- ORDレコード
- ord-752a37789e40439aa8ed5c01edd05f31
- 出典データセット
- uspto-grants-2007_09
- 特許番号
- US07268230B2
反応ノート
読み込み中…