Thionyl Chloride → HCID 87822203、化合物
反応式
[CH:1]1[C:13]2[CH:12]([CH2:14][CH2:15][N:16]([CH3:22])[CH2:17][CH2:18][C:19](O)=[O:20])[C:11]3[C:6](=[CH:7][CH:8]=[CH:9][CH:10]=3)[C:5]=2[CH:4]=[CH:3][CH:2]=1.S(Cl)([Cl:25])=O>ClC(Cl)C>[ClH:25].[CH:1]1[C:13]2[CH:12]([CH2:14][CH2:15][N:16]([CH3:22])[CH2:17][CH2:18][C:19]([Cl:25])=[O:20])[C:11]3[C:6](=[CH:7][CH:8]=[CH:9][CH:10]=3)[C:5]=2[CH:4]=[CH:3][CH:2]=1参加物
4
実験手順
A solution of 3-{[2-(9H-fluoren-9-yl)-ethyl]-methyl-amino}-propionic acid (11.4 g) in dichloroethane (115 ml) is treated with thionyl chloride (7.71 g) at room temperature for 5′ and at 60° for 1 hour. About 20 ml volatiles are removed under reduced pressure. 100 ml diethyl ether are added and the mixture kept at 5° over night for crystallization. The crystals are collected by filtration, washed with dichloroethane/diethylether and dried. M.p. 120°-123°.