6-Azido-4-[2-(6-fluoro-pyridin-2-yl)-imidazol-1-ylmethyl]-5-propyl-pyrimidine → 6-Amino-4-[2-(6-fluoro-pyridin-2-yl)-imidazol-1-ylmethyl]-5-propyl-pyrimidine

HRID 916639ノート

反応式

HRID 916639 の反応式
[N:1]([C:4]1[N:9]=[CH:8][N:7]=[C:6]([CH2:10][N:11]2[CH:15]=[CH:14][N:13]=[C:12]2[C:16]2[CH:21]=[CH:20][CH:19]=[C:18]([F:22])[N:17]=2)[C:5]=1[CH2:23][CH2:24][CH3:25])=[N+]=[N-]>CO.[Pd]>[NH2:1][C:4]1[N:9]=[CH:8][N:7]=[C:6]([CH2:10][N:11]2[CH:15]=[CH:14][N:13]=[C:12]2[C:16]2[CH:21]=[CH:20][CH:19]=[C:18]([F:22])[N:17]=2)[C:5]=1[CH2:23][CH2:24][CH3:25]

参加物

4

反応物 1

HCID 223131686-Azido-4-[2-(6-fluoro-pyridin-2-yl)-imidazol-1-ylmethyl]-5-propyl-pyrimidine

生成物 1

HCID 117230296-Amino-4-[2-(6-fluoro-pyridin-2-yl)-imidazol-1-ylmethyl]-5-propyl-pyrimidine

試薬・触媒・溶媒 2

HCID 23938Palladium触媒HCID 887Methanol溶媒

実験手順

Pd/C (10%, 10 mg) is added to a solution of 104 (2 mmol) in MeOH (20 ml). The mixture is stirred under H2 at 30 psi for 4 hours. The catalyst is removed by filtration and the filtrate is evaporated in vacuo. The light resulting yellow solid (105) is used in the next step without further purification.

後処理

  1. customThe catalyst is removed by filtration
  2. customthe filtrate is evaporated in vacuo

出典と根拠

ORDレコード
ord-fd5ed461658f4a5e994264ca3414b1ec
出典データセット
uspto-grants-2007_09
特許番号
US07271170B2

反応ノート

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