1-[2-(Benzyloxy)ethoxy]-4-(2-bromoethyl)benzene → 2-[4-(2-Bromoethyl)phenoxy]ethanol
反応式
C([O:8][CH2:9][CH2:10][O:11][C:12]1[CH:17]=[CH:16][C:15]([CH2:18][CH2:19][Br:20])=[CH:14][CH:13]=1)C1C=CC=CC=1>CCOC(C)=O.CCO.[Pd]>[Br:20][CH2:19][CH2:18][C:15]1[CH:16]=[CH:17][C:12]([O:11][CH2:10][CH2:9][OH:8])=[CH:13][CH:14]=1参加物
5
実験手順
1-[2-(benzyloxy)ethoxy]-4-(2-bromoethyl)benzene in EtOAc (150 mL) and EtOH (50 mL) was hydrogenated over 10% Pd/C (530 mg) at room temperature and atmospheric pressure for 8 h. The catalyst was removed by filtration over Celite, washed with EtOAc and concentrated in vacuo to give the title compound (3.6 g). LCMS RT=2.82 min.
後処理
- customThe catalyst was removed by filtration over Celite
- washwashed with EtOAc
- concentrationconcentrated in vacuo
出典と根拠
- ORDレコード
- ord-dc5a031a0e4543a8a902e51c9fdb3279
- 出典データセット
- uspto-grants-2007_09
- 特許番号
- US07271197B2
反応ノート
読み込み中…