3-(4-Hydroxybut-1-ynyl)phenyl acetate → HCID 68981033、化合物
反応式
[C:1]([O:4][C:5]1[CH:10]=[CH:9][CH:8]=[C:7]([C:11]#[C:12][CH2:13][CH2:14][OH:15])[CH:6]=1)(=[O:3])[CH3:2]>C(OCC)(=O)C.C(O)C.[Pd]>[C:1]([O:4][C:5]1[CH:10]=[CH:9][CH:8]=[C:7]([CH2:11][CH2:12][CH2:13][CH2:14][OH:15])[CH:6]=1)(=[O:3])[CH3:2]参加物
5
実験手順
A solution of 3-(4-hydroxybut-1-ynyl)phenyl acetate (4.47 g) was hydrogenated over 5% Pd on carbon in ethyl acetate (100 mL) and ethanol (100 mL) over 20 h. The reaction mixture was filtered through celite under nitrogen, and the filtrate was concentrated in vacua. The residue was purified by chromatography (SPE, gradient from cyclohexane to EtOAc) to give the title compound. LCMS RT=2.64 min
後処理
- filtrationThe reaction mixture was filtered through celite under nitrogen
- concentrationthe filtrate was concentrated in vacua
- customThe residue was purified by chromatography (SPE, gradient from cyclohexane to EtOAc)
出典と根拠
- ORDレコード
- ord-4371f1abf2874ab6b921aeff0b4848f1
- 出典データセット
- uspto-grants-2007_09
- 特許番号
- US07271197B2
反応ノート
読み込み中…