Hydrochloric Acid → 6-Amino-2-(trifluoromethyl)-1H-imidazo[4,5-b]pyridin-1-ol

HRID 917851ノート

反応式

HRID 917851 の反応式
[N+:1]([C:4]1[CH:5]=[C:6]2[N:12]([OH:13])[C:11]([C:14]([F:17])([F:16])[F:15])=[N:10][C:7]2=[N:8][CH:9]=1)([O-])=O.C(O)C.Cl.[H][H]>O.[Pd]>[NH2:1][C:4]1[CH:5]=[C:6]2[N:12]([OH:13])[C:11]([C:14]([F:15])([F:17])[F:16])=[N:10][C:7]2=[N:8][CH:9]=1

参加物

7

反応物 4

HCID 313Hydrochloric AcidHCID 702EthanolHCID 203554946-Nitro-2-(trifluoromethyl)-1H-imidazo[4,5-b]pyridin-1-olHCID 178418361HCID 178418361、化合物

生成物 1

HCID 203554676-Amino-2-(trifluoromethyl)-1H-imidazo[4,5-b]pyridin-1-ol

試薬・触媒・溶媒 2

HCID 23938Palladium触媒HCID 962Water溶媒

実験手順

6-Nitro-1-hydroxy-2-(trifluoromethyl)-1H-imidazo(4,5-b)-pyridine (4.9 grams) was mixed with 100 milliliters of ethanol and 3 milliliters of concentrated hydrochloric acid, and 1 gram of 5 percent palladium or carbon was added to the mixture. The mixture was hydrogenated to a 3 mole-equivalent uptake of hydrogen. The reaction mixture was then filtered and evaporated, yielding a gummy solid residue which was taken up in 150 milliliters of water and used directly in the reaction reported in the following example.

後処理

  1. additionwas added to the mixture
  2. filtrationThe reaction mixture was then filtered
  3. customevaporated
  4. customyielding a gummy solid residue which

出典と根拠

ORDレコード
ord-811f71766df849f6b0f17243c0a958c3
出典データセット
uspto-grants-1976_07
特許番号
US03968116

反応ノート

読み込み中…