Thionyl Chloride → 29030-58-8

HRID 917916ノート

反応式

HRID 917916 の反応式
[CH:1]1([C:7]2[CH:12]=[CH:11][C:10]([CH2:13][C:14]([NH2:16])=O)=[CH:9][CH:8]=2)[CH2:6][CH2:5][CH2:4][CH2:3][CH2:2]1.S(Cl)(Cl)=O>>[CH:1]1([C:7]2[CH:8]=[CH:9][C:10]([CH2:13][C:14]#[N:16])=[CH:11][CH:12]=2)[CH2:2][CH2:3][CH2:4][CH2:5][CH2:6]1

参加物

3

反応物 2

HCID 24386Thionyl ChlorideHCID 13030798HCID 13030798、化合物

生成物 1

HCID 2024547429030-58-8

実験手順

17.3 g of para-cyclohexyl-phenylacetamide and 35 ml of thionyl chloride are stirred at 70°C for 3 hours. The excess thionyl chloride is evaporated, the residue dissolved in ethyl acetate, and the solution washed with sodium bicarbonate solution and water. The solvent is evaporated and the residue distilled in a high vacuum. There is obtained paracyclohexylphenylacetonitrile boiling at 131°-132°C under a pressure of 0.35 mm of Hg and melting at 48°-49°C.

後処理

  1. customThe excess thionyl chloride is evaporated
  2. dissolutionthe residue dissolved in ethyl acetate
  3. washthe solution washed with sodium bicarbonate solution and water
  4. customThe solvent is evaporated
  5. distillationthe residue distilled in a high vacuum

出典と根拠

ORDレコード
ord-ba90b6daa13f4762869b6b85a7d2c976
出典データセット
uspto-grants-1976_07
特許番号
US03968142

反応ノート

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