(-)-1-(N-methylanthraniloyl)-proline → 10-methyl-2,3-dihydro-1H-pyrrolo[2,1-c][1,4]benzodiazepine-5,11(10H,11aH)-dione
反応式
[CH3:1][NH:2][C:3]1[C:4](=[CH:15][CH:16]=[CH:17][CH:18]=1)[C:5]([N:7]1[CH2:14][CH2:13][CH2:12][C@H:8]1[C:9](O)=[O:10])=[O:6]>O1CCCC1>[CH3:1][N:2]1[C:3]2[CH:18]=[CH:17][CH:16]=[CH:15][C:4]=2[C:5](=[O:6])[N:7]2[CH2:14][CH2:13][CH2:12][CH:8]2[C:9]1=[O:10]参加物
3
実験手順
A mixture of 24.8 g. of (-)-1-(N-methylanthraniloyl)proline and 18.0 g. of N,N'-carbonyldiimidazole in 300 ml. of dry tetrahydrofuran is stirred for 2 hours at room temperature and then heated at reflux temperature for 3 hours. The reaction mixture is concentrated to remove the solvent and the residue is extracted into benzene. The benzene solution is washed twice with water and concentrated to recover the desired product.
後処理
- additionA mixture of 24.8 g
- temperatureheated
- temperatureat reflux temperature for 3 hours
- concentrationThe reaction mixture is concentrated
- customto remove the solvent
- extractionthe residue is extracted into benzene
- washThe benzene solution is washed twice with water
- concentrationconcentrated
- customto recover the desired product
出典と根拠
- ORDレコード
- ord-a9760acb26c648a18ae773d7462e2c88
- 出典データセット
- uspto-grants-1976_07
- 特許番号
- US03968230
反応ノート
読み込み中…