Diethylene Glycol → 4-[alpha-amino-alpha-amino-alpha-phenyl-o-tolyl]-5-ethyl-4H-1,2,4-triazole-3-carboxaldehyde
反応式
Cl[C:2]1[CH:3]=[CH:4][C:5]2[N:11]3[C:12]([CH:15]4C[CH2:16]4)=[N:13][N:14]=C3C[N:8]=[C:7]([C:18]3[CH:23]=[CH:22][CH:21]=[CH:20][C:19]=3Cl)[C:6]=2[CH:25]=1.C([NH:29]N)CC.C(O)CO[CH2:34][CH2:35][OH:36]>>[NH2:29][C:7]([NH2:8])([C:18]1[CH:23]=[CH:22][CH:21]=[CH:20][CH:19]=1)[C:6]1[CH:25]=[CH:2][CH:3]=[CH:4][C:5]=1[N:11]1[C:12]([CH2:15][CH3:16])=[N:13][N:14]=[C:34]1[CH:35]=[O:36]参加物
4
実験手順
In the manner given in Examples 1-7, above, 1ethyl-6-phenyl-4H-s-triazolo[ 4,3-a][1,4]benzodiazepine (III) in diethylene glycol is treated with propyl hydrazine to obtain both A and B 4-[α-amino-α-amino-α-phenyl-o-tolyl]-5-ethyl -4H-1,2,4-triazole-3-carboxaldehyde, propylhydrazone, which is separated by column chromatography into the two diastereomers A and B.