Hydrochloric Acid → 21-Chloro-11beta,17-dihydroxy-16alpha-(2-mesyloxyethoxy)pregna-1,4-diene-3,20-dione

HRID 918417ノート

反応式

HRID 918417 の反応式
[Cl:1][CH2:2][C:3](=[O:30])[C@:4]1([OH:29])[C@:21]2([CH3:22])[C@H:7]([C@H:8]3[C@H:18]([C@@H:19]([OH:23])[CH2:20]2)[C@:16]2([CH3:17])[C:11](=[CH:12][C:13](=[O:24])[CH:14]=[CH:15]2)[CH2:10][CH2:9]3)[CH2:6][C@H:5]1[O:25][CH2:26][CH2:27][OH:28].[CH3:31][S:32](Cl)(=[O:34])=[O:33].Cl>N1C=CC=CC=1>[Cl:1][CH2:2][C:3](=[O:30])[C@:4]1([OH:29])[C@:21]2([CH3:22])[C@H:7]([C@H:8]3[C@H:18]([C@@H:19]([OH:23])[CH2:20]2)[C@:16]2([CH3:17])[C:11](=[CH:12][C:13](=[O:24])[CH:14]=[CH:15]2)[CH2:10][CH2:9]3)[CH2:6][C@H:5]1[O:25][CH2:26][CH2:27][O:28][S:32]([CH3:31])(=[O:34])=[O:33]

参加物

5

反応物 3

HCID 313Hydrochloric AcidHCID 31297Methanesulfonyl chlorideHCID 8673376021-Chloro-11beta,17-dihydroxy-16alpha-(2-hydroxyethoxy)pregna-1,4-diene-3,20-dione

生成物 1

HCID 8673376121-Chloro-11beta,17-dihydroxy-16alpha-(2-mesyloxyethoxy)pregna-1,4-diene-3,20-dione

試薬・触媒・溶媒 1

HCID 1049Pyridine溶媒

実験手順

A solution of 21-chloro-11β,17-dihydroxy-16α-(2-hydroxyethoxy)pregna-1,4-diene-3,20-dione (7.6 mmoles) in 30 ml of pyridine is cooled to 0°C and 1 ml of methanesulfonyl chloride is added. After 2 hours the mixture is poured into cold dilute hydrochloric acid and extracted with chloroform. The chloroform solution is dried and evaporated in vacuo to yield the title compound.

後処理

  1. extractionextracted with chloroform
  2. dry with materialThe chloroform solution is dried
  3. customevaporated in vacuo

出典と根拠

ORDレコード
ord-ce70573a3aed435a8288f2b2e7890bd9
出典データセット
uspto-grants-1976_07
特許番号
US03971773

反応ノート

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