Sodium Hydroxide → 3-Amino-4-phenoxy-5-sulfamoylbenzoic acid

HRID 918654

反応式

HRID 918654 の反応式
[NH2:1][C:2]1[CH:3]=[C:4]([CH:8]=[C:9]([S:18](=[O:21])(=[O:20])[NH2:19])[C:10]=1[O:11][C:12]1[CH:17]=[CH:16][CH:15]=[CH:14][CH:13]=1)[C:5](N)=[O:6].[OH-:22].[Na+]>>[NH2:1][C:2]1[CH:3]=[C:4]([CH:8]=[C:9]([S:18](=[O:21])(=[O:20])[NH2:19])[C:10]=1[O:11][C:12]1[CH:17]=[CH:16][CH:15]=[CH:14][CH:13]=1)[C:5]([OH:22])=[O:6]

参加物

3

反応物 2

HCID 14798Sodium HydroxideHCID 215060743-Amino-4-phenoxy-5-sulphamyl-benzamide

生成物 1

HCID 1199273-Amino-4-phenoxy-5-sulfamoylbenzoic acid

実験手順

A mixture of 3-amino-4-phenoxy-5-sulphamyl-benzamide (1 g) and 1N sodium hydroxide (20 ml) was refluxed for 1 hour. After cooling, the 3-amino-4-phenoxy-5-sulphamyl-benzoic acid was precipitated from the reaction mixture by addition of 4N hydrochloric acid until pH 2.5. After several recrystallizations from aqueous ethanol and drying, the compound was obtained with a melting point of 252°-253°C.

後処理

  1. temperaturewas refluxed for 1 hour
  2. temperatureAfter cooling
  3. customthe 3-amino-4-phenoxy-5-sulphamyl-benzoic acid was precipitated from the reaction mixture by addition of 4N hydrochloric acid until pH 2.5
  4. customAfter several recrystallizations from aqueous ethanol
  5. customdrying
  6. customthe compound was obtained with a melting point of 252°-253°C.

出典と根拠

ORDレコード
ord-16b81e99edb841e085ac215f84a24b02
出典データセット
uspto-grants-1976_07
特許番号
US03971819

関連ノート

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