Methanol → Methyl 3-phenoxypropionate

HRID 919023

反応式

HRID 919023 の反応式
[O:1]([CH2:8][CH2:9][C:10]([OH:12])=[O:11])[C:2]1[CH:7]=[CH:6][CH:5]=[CH:4][CH:3]=1.[CH3:13]O>OS(O)(=O)=O>[O:1]([CH2:8][CH2:9][C:10]([O:12][CH3:13])=[O:11])[C:2]1[CH:7]=[CH:6][CH:5]=[CH:4][CH:3]=1

参加物

4

反応物 2

HCID 887MethanolHCID 815963-Phenoxypropionic acid

生成物 1

HCID 347927Methyl 3-phenoxypropionate収率 92.5%

試薬・触媒・溶媒 1

HCID 1118Sulfuric Acid触媒

実験手順

3-phenoxypropionic acid (5.0 g, 30 mmol) was dissolved in MeOH (12 mL) and H2SO4 (18 M, 3 drops) was added. The mixture was place in the microwave reactor (T: 140° C., t: 5 min). The solvent was evaporated, the mixture was partitioned in EtOAc (30 mL) and NaOH (2N, 20 mL). The organic phase was dried over MgSO4, filtered, and evaporated to give methyl 3-phenoxypropanoate (5.0 g, 27.7 mmol, 92.5%).

後処理

  1. customin the microwave reactor (T: 140° C., t: 5 min)
  2. customThe solvent was evaporated
  3. customthe mixture was partitioned in EtOAc (30 mL)
  4. dry with materialThe organic phase was dried over MgSO4
  5. filtrationfiltered
  6. customevaporated

出典と根拠

ORDレコード
ord-82e83209270646fab7c83a246bd433a0
出典データセット
uspto-grants-2016_03
特許番号
US09272996B2

関連ノート

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