Hydrochloric Acid → 3-[4-(Hydroxymethyl)phenyl]propanoic acid
反応式
C[CH:2]([CH2:6][C:7]1[CH:12]=[CH:11][C:10]([CH2:13][OH:14])=[CH:9][CH:8]=1)[C:3]([OH:5])=[O:4].[Li+].[OH-].Cl>CO.O>[OH:14][CH2:13][C:10]1[CH:11]=[CH:12][C:7]([CH2:6][CH2:2][C:3]([OH:5])=[O:4])=[CH:8][CH:9]=1参加物
6
実験手順
Intermediate B (5 g, 25.7 mmol) was dissolved in MeOH (50 mL) and water (10 mL). LiOH (1.85 g, 77.2 mmol) was added and the reaction stirred at RT for 18 h. The reaction mixture was acidified to pH ˜3 with 1M HCl, the resulting precipitate was isolated by filtration to afford the desired product (4.57 g, quant.). 1H NMR (300 MHz, d6-DMSO) δ: 7.18 (4H, q), 4.45 (2H, d), 2.81 (2H, t), 2.62 (2H, t).
後処理
- customthe resulting precipitate was isolated by filtration
出典と根拠
- ORDレコード
- ord-3e276ce1c7c5425b982a303dbcf8dc8b
- 出典データセット
- uspto-grants-2016_03
- 特許番号
- US09273003B2
反応ノート
読み込み中…