Water → 5,6-Dichloro-1,3-Dihydro-2H-Benzimidazol-2-One

HRID 919357

反応式

HRID 919357 の反応式
[Cl:1][C:2]1[CH:3]=[C:4]([NH2:10])[C:5]([NH2:9])=[CH:6][C:7]=1[Cl:8].C1N=CN([C:16](N2C=NC=C2)=[O:17])C=1.O>CN(C=O)C>[Cl:1][C:2]1[C:7]([Cl:8])=[CH:6][C:5]2[NH:9][C:16](=[O:17])[NH:10][C:4]=2[CH:3]=1

参加物

5

反応物 3

HCID 962WaterHCID 682631,1'-CarbonyldiimidazoleHCID 792974,5-Dichloro-1,2-phenylenediamine

生成物 1

HCID 98991485,6-Dichloro-1,3-Dihydro-2H-Benzimidazol-2-One収率 91.5%

試薬・触媒・溶媒 1

HCID 6228Dimethylformamide溶媒

実験手順

To the solution of 4,5-dichloro-benzene-1,2-diamine (25 g, 0.14 mol) in dry DMF (200 mL), was added CDI (23 g, 0.14 mol) as the solid. The reaction solution was stirred at room temperature for 1 hour, then water (500 mL) was added. The precipitated solid was collected by filtration, washed with water, dried thoroughly to afford the titled compound (26.0 g, 90%). The crude product was used in the following reaction without further purification.

後処理

  1. filtrationThe precipitated solid was collected by filtration
  2. washwashed with water
  3. customdried thoroughly

出典と根拠

ORDレコード
ord-d736183869774be2acd93ff99c6c46df
出典データセット
uspto-grants-2016_03
特許番号
US09273034B2

関連ノート

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