Sodium borohydride → 1-(Isoquinolin-8-yl)ethan-1-ol
反応式
[CH:1]1[C:10]2[C:5](=[CH:6][CH:7]=[CH:8][C:9]=2[C:11](=[O:13])[CH3:12])[CH:4]=[CH:3][N:2]=1.[BH4-].[Na+]>CCO>[CH:1]1[C:10]2[C:5](=[CH:6][CH:7]=[CH:8][C:9]=2[CH:11]([OH:13])[CH3:12])[CH:4]=[CH:3][N:2]=1参加物
4
実験手順
1-(isoquinolin-8-yl)ethanone (0.64 g, 3.74 mmol) in EtOH (37 mL) was added with sodium borohydride (2.26 g, 59.8 mmol). The reaction mixture was stirred overnight. The reaction mixture was quenched with 1M NaOH and extracted with DCM. Purified by normal phase chromatography (10-60% EtOAc in hexane) to yield 1-(isoquinolin-8-yl)ethanol as an oil. Chiral separation (ChiralPak AD-H) provided (S)-1-(isoquinolin-8-yl)ethanol and (R)-1-(isoquinolin-8-yl)ethanol.
後処理
- customThe reaction mixture was quenched with 1M NaOH
- extractionextracted with DCM
- customPurified by normal phase chromatography (10-60% EtOAc in hexane)
出典と根拠
- ORDレコード
- ord-8368ae2540fb4ea99bdb01974583b9eb
- 出典データセット
- uspto-grants-2016_03
- 特許番号
- US09273040B2
反応ノート
読み込み中…