Hydrazine hydrate (1:1) → 7-(pyridin-4-yl)thieno[3,2-d]pyridazin-4(5H)-one

HRID 920902ノート

反応式

HRID 920902 の反応式
[C:1]([C:9]1[S:10][CH:11]=[CH:12][C:13]=1[C:14]([O:16]CC)=O)(=O)[C:2]1[CH:7]=[CH:6][N:5]=[CH:4][CH:3]=1.[NH2:19][NH2:20].O>CCO>[N:5]1[CH:6]=[CH:7][C:2]([C:1]2[C:9]3[S:10][CH:11]=[CH:12][C:13]=3[C:14](=[O:16])[NH:19][N:20]=2)=[CH:3][CH:4]=1

参加物

4

反応物 2

HCID 24654Hydrazine hydrate (1:1)HCID 86683117Ethyl 2-isonicotinoylthiophene-3-carboxylate

生成物 1

HCID 866831187-(pyridin-4-yl)thieno[3,2-d]pyridazin-4(5H)-one収率 85.1%

試薬・触媒・溶媒 1

HCID 702Ethanol溶媒

実験手順

The mixture of ethyl 2-isonicotinoylthiophene-3-carboxylate (200 mg, 0.77 mmol) from example 2.2 in NH2NH2.H2O (2 mL) and EtOH (10 mL) was stirred at room temperature for 30 min. The mixture was filtered and the solid dried to obtain the title compound (150 mg, 85.1% yield).

後処理

  1. filtrationThe mixture was filtered
  2. customthe solid dried

出典と根拠

ORDレコード
ord-1486e61f12834859b396a2cbe561b3cc
出典データセット
uspto-grants-2016_03
特許番号
US09273068B2

反応ノート

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