Hydrochloric Acid → HCID 86683146、化合物

HRID 920932ノート

反応式

HRID 920932 の反応式
[N:1]1[C:2]([CH2:10][CH2:11][N:12]2[C:21](=[O:22])[C:20]3[C:15](=[CH:16][CH:17]=[CH:18][C:19]=3[NH:23][C@@H:24]3[CH2:28][CH2:27][N:26](C(OC(C)(C)C)=O)[CH2:25]3)[CH:14]=[N:13]2)=[CH:3][N:4]2[CH:9]=[CH:8][CH:7]=[CH:6][C:5]=12.[ClH:36].C(OC(C)C)(C)C>C(Cl)Cl.C(O)(C)C>[ClH:36].[ClH:36].[N:1]1[C:2]([CH2:10][CH2:11][N:12]2[N:13]=[CH:14][C:15]3[C:20](=[C:19]([NH:23][C@@H:24]4[CH2:28][CH2:27][NH:26][CH2:25]4)[CH:18]=[CH:17][CH:16]=3)[C:21]2=[O:22])=[CH:3][N:4]2[CH:9]=[CH:8][CH:7]=[CH:6][C:5]=12

参加物

6

反応物 3

HCID 313Hydrochloric AcidHCID 7914Diisopropyl Ether2 回HCID 86683144HCID 86683144、化合物

生成物 1

HCID 86683146HCID 86683146、化合物

試薬・触媒・溶媒 2

HCID 3776Isopropanol溶媒2 回HCID 6344Dichloromethane溶媒

実験手順

A solution of (R)-tert-butyl 3-(3-(2-(imidazo[1,2-a]pyridin-2-yl)ethyl)-4-oxo-3,4-dihydrophthalazin-5-ylamino)pyrrolidine-1-carboxylate from Example 218 (52 mg, 0.110 mmol) in 20 mL of DCM was mixed with 1 mL of HCl containing isopropanol and the reaction mixture was stirred under nitrogen for 12 h at room temperature. The reaction mixture was mixed with diisopropyl ether and the supernatant was discharged. Then, the residue was dissolved in isopropanol and diisopropyl ether was added. The supernatant was discharged. The precipitate was dried to give 24 mg of a yellow salt as solid foam. LC-MS: m/e=357.2 (M+H)+

後処理

  1. customThe precipitate was dried

出典と根拠

ORDレコード
ord-9a7eb7f8014f4d34b7aade20e8ee7388
出典データセット
uspto-grants-2016_03
特許番号
US09273068B2

反応ノート

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