Chloroacetaldehyde → Imidazo(1,2-a)pyrazine
反応式
[N:1]1[CH:6]=[CH:5][N:4]=[CH:3][C:2]=1[NH2:7].Cl[CH2:9][CH:10]=O.C(=O)(O)[O-].[Na+]>C(=O)([O-])[O-].[K+].[K+]>[N:7]1[CH:9]=[CH:10][N:1]2[CH:6]=[CH:5][N:4]=[CH:3][C:2]=12参加物
5
反応条件
- 温度
- 100 °C
実験手順
Pyrazin-2-amine 4a (5 g, 52 mmol) was dissolved in a 40% 2-chloroacetaldehyde solution (15 mL, 78 mmol), followed by addition of sodium bicarbonate (6.60 g, 78 mmol). After stirring for 48 hours at 100° C., the reaction mixture was cooled to room temperature, added with 100 mL of a saturated potassium carbonate solution, and extracted with dichloromethane (100 mL×3). The organic phase was combined, dried over anhydrous sodium sulfate and filtered. The filtrate was concentrated under reduced pressure to obtain imidazo[1,2-a]pyrazine 4b (3 g, yield 50.0%) as a brown solid.
後処理
- temperaturethe reaction mixture was cooled to room temperature
- extractionextracted with dichloromethane (100 mL×3)
- dry with materialdried over anhydrous sodium sulfate
- filtrationfiltered
- concentrationThe filtrate was concentrated under reduced pressure
出典と根拠
- ORDレコード
- ord-18e409b58c634ae8986b858380f617b3
- 出典データセット
- uspto-grants-2016_03
- 特許番号
- US09273052B2
反応ノート
読み込み中…