(3-Methoxy-4-nitrophenyl)(dimethyl)phosphane oxide → (4-Amino-3-methoxyphenyl)dimethylphosphine oxide
反応式
[CH3:1][O:2][C:3]1[CH:4]=[C:5]([P:12](=[O:15])([CH3:14])[CH3:13])[CH:6]=[CH:7][C:8]=1[N+:9]([O-])=O>CCO.[Pd]>[CH3:14][P:12]([C:5]1[CH:6]=[CH:7][C:8]([NH2:9])=[C:3]([O:2][CH3:1])[CH:4]=1)([CH3:13])=[O:15]参加物
4
実験手順
To a solution of (3-methoxy-4-nitrophenyl)(dimethyl)phosphane oxide (0.1 g, 0.44 mmol) in 5 mL of EtOH was added 10% weight of palladium on carbon (0.2 g). The mixture was purged with argon, and hydrogenated under 30 psi for 2 h. The mixture was passed through Celite to a flask containing HCl in ethanol. Concentration of the filtrate gave the final product (0.088 g, 86% yield). MS/ES+: m/z=199.
後処理
- customThe mixture was purged with argon
- customThe mixture was passed through Celite to a flask
- additioncontaining HCl in ethanol
出典と根拠
- ORDレコード
- ord-9901cf3965a74f758c803df2a970e4ea
- 出典データセット
- uspto-grants-2016_03
- 特許番号
- US09273077B2
反応ノート
読み込み中…