1-Bromononane → HCID 86708420、化合物

HRID 921482ノート

反応式

HRID 921482 の反応式
[CH2:1]([CH:3]([CH2:6][CH:7]([CH2:10][CH3:11])[CH2:8][OH:9])[CH2:4][OH:5])[CH3:2].[CH2:12](Br)[CH2:13][CH2:14][CH2:15][CH2:16][CH2:17][CH2:18][CH2:19][CH3:20].[OH-].[Na+]>[Br-].C([N+](CCCC)(CCCC)CCCC)CCC>[CH2:12]([O:9][CH2:8][CH:7]([CH2:10][CH3:11])[CH2:6][CH:3]([CH2:1][CH3:2])[CH2:4][OH:5])[CH2:13][CH2:14][CH2:15][CH2:16][CH2:17][CH2:18][CH2:19][CH3:20]

参加物

5

反応物 3

HCID 127421-BromononaneHCID 14798Sodium HydroxideHCID 113441631,5-Pentanediol, 2,4-diethyl-

生成物 1

HCID 86708420HCID 86708420、化合物

試薬・触媒・溶媒 1

HCID 74236Tetrabutylammonium Bromide触媒

反応条件

温度
75 °C

実験手順

Under nitrogen stream, to a 2-L reactor provided with a stirrer, thermometer, condenser and gas inlet tube, 320 g (2 mol) of 2,4-diethyl-1,5-pentanediol, 311 g (1.5 mol) of n-nonylbromide and 12 g of tetrabutylammonium bromide were put, to which 532 g of 52 mass/volume % aqueous sodium hydroxide was added and heated at 70 to 80 degrees C. for six hours with stirring. After the reaction, the mixture was cooled and left still overnight to deposit white crystal. A liquid layer is transferred to a separating funnel by decantation. The white crystal was washed with 20 mL of hexane. The washing liquid of hexane was added to the liquid layer.

後処理

  1. customUnder nitrogen stream, to a 2-L reactor provided with a stirrer
  2. customAfter the reaction
  3. temperaturethe mixture was cooled
  4. waitleft still overnight
  5. customA liquid layer is transferred to a separating funnel by decantation
  6. washThe white crystal was washed with 20 mL of hexane
  7. additionThe washing liquid of hexane was added to the liquid layer

出典と根拠

ORDレコード
ord-20608b5d460543e988e64fcf5ed33d3f
出典データセット
uspto-grants-2016_03
特許番号
US09273264B2

反応ノート

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