Benzyl 3-(4-methylpiperazin-1-yl)azetidine-1-carboxylate → 1-(Azetidin-3-yl)-4-methylpiperazine

HRID 921642ノート

反応式

HRID 921642 の反応式
[CH3:1][N:2]1[CH2:7][CH2:6][N:5]([CH:8]2[CH2:11][N:10](C(OCC3C=CC=CC=3)=O)[CH2:9]2)[CH2:4][CH2:3]1>CO.[Pd]>[NH:10]1[CH2:11][CH:8]([N:5]2[CH2:6][CH2:7][N:2]([CH3:1])[CH2:3][CH2:4]2)[CH2:9]1

参加物

4

反応物 1

HCID 86708494Benzyl 3-(4-methylpiperazin-1-yl)azetidine-1-carboxylate

生成物 1

HCID 206598001-(Azetidin-3-yl)-4-methylpiperazine収率 100.2%

試薬・触媒・溶媒 2

HCID 23938Palladium触媒HCID 887Methanol溶媒

実験手順

A mixture of benzyl 3-(4-methylpiperazin-1-yl)azetidine-1-carboxylate (1.45 g, 5.01 mmol) and Pd/C (0.320 g, 0.150 mmol) in methanol (30 mL) was hydrogenated at 30 psi over the weekend. The reaction mixture was filtered through celite and the filtrate was concentrated. The crude product 1-(azetidin-3-yl)-4-methylpiperazine (0.78 g, 5.02 mmol, 100% yield) was obtained as colorless oil and used without purification.

後処理

  1. filtrationThe reaction mixture was filtered through celite
  2. concentrationthe filtrate was concentrated

出典と根拠

ORDレコード
ord-a635ec9e7d954fdb96254ca6fa06cd72
出典データセット
uspto-grants-2016_03
特許番号
US09273057B2

反応ノート

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