Hydrochloric Acid → 3-(4-Hydroxyphenyl)hex-4-ynoic acid

HRID 922269ノート

反応式

HRID 922269 の反応式
[OH:1][C:2]1[CH:7]=[CH:6][C:5]([CH:8]([CH:12]2C(=O)OC(C)(C)[O:14][C:13]2=[O:21])[C:9]#[C:10][CH3:11])=[CH:4][CH:3]=1.O.Cl>C(C(CC)=O)C>[OH:1][C:2]1[CH:3]=[CH:4][C:5]([CH:8]([C:9]#[C:10][CH3:11])[CH2:12][C:13]([OH:21])=[O:14])=[CH:6][CH:7]=1

参加物

5

反応物 3

HCID 313Hydrochloric AcidHCID 962WaterHCID 598551335-(1-(4-Hydroxyphenyl)but-2-yn-1-yl)-2,2-dimethyl-1,3-dioxane-4,6-dione

生成物 1

HCID 598551363-(4-Hydroxyphenyl)hex-4-ynoic acid収率 100%

試薬・触媒・溶媒 1

HCID 7288Ethyl ketone溶媒

実験手順

To a 250 mL 3-necked RB flask fitted with magnetic stirrer was charged with 5-[1-(4-hydroxyphenyl)but-2-yn-1-yl]-2,2-dimethyl-1,3-dioxane-4,6-dione (5.8 g, 20.13 mmol) in diethyl ketone was added water (13 mL), the reaction mixture was heated to refluxed for 48 h. The RM was acidified with 1N HCl and extracted with ethyl acetate. The organic layer was washed with water, dried over anhydrous sodium sulphat. Finally removal of solvent under reduced pressure to obtain the product (4.11 g, yield: 100.0%).

後処理

  1. customTo a 250 mL 3-necked RB flask fitted with magnetic stirrer
  2. temperaturethe reaction mixture was heated
  3. temperatureto refluxed for 48 h
  4. extractionextracted with ethyl acetate
  5. washThe organic layer was washed with water
  6. dry with materialdried over anhydrous sodium sulphat
  7. customFinally removal of solvent under reduced pressure

出典と根拠

ORDレコード
ord-41fff5c63dc54b33b6a24ec418b79b06
出典データセット
uspto-grants-2016_03
特許番号
US09278915B2

反応ノート

読み込み中…