Water → (S)-1-Boc-3-methanesulfonyloxy-pyrrolidine
反応式
[C:1]([N:8]1[CH2:12][CH2:11][C@H:10]([OH:13])[CH2:9]1)([O:3][C:4]([CH3:7])([CH3:6])[CH3:5])=[O:2].[CH3:14][S:15](Cl)(=[O:17])=[O:16].O>C1COCC1>[C:4]([O:3][C:1]([N:8]1[CH2:12][CH2:11][C@H:10]([O:13][S:15]([CH3:14])(=[O:17])=[O:16])[CH2:9]1)=[O:2])([CH3:7])([CH3:6])[CH3:5]参加物
5
実験手順
To 3.44 g (187 mmol) (S)-1-Boc-3-pyrrolidinol in 15 ml THF are added 1.70 mL (21.6 mmol) of methanesulfonyl chloride at 0° C. The reaction mixture is stirred for 1 h. Water is added and it is extracted with EtOAc (3×). The organic layer is washed with an aq. NaHCO3 solution and dried over MgSO4. The solvent is removed in vacuo.
後処理
- extractionit is extracted with EtOAc (3×)
- washThe organic layer is washed with an aq. NaHCO3 solution
- dry with materialdried over MgSO4
- customThe solvent is removed in vacuo
出典と根拠
- ORDレコード
- ord-0a090a72c35e45f3a1fae04bdafe52a4
- 出典データセット
- uspto-grants-2016_03
- 特許番号
- US09278954B2
反応ノート
読み込み中…