Potassium Hydroxide → HCID 71467656、化合物

反応式

[Cl:1][C:2]1[N:3]=[CH:4][NH:5][C:6]=1[Cl:7].[OH-:8].[K+].[Br:10][CH2:11][C:12]1[CH:22]=[CH:21][C:15]([O:16][CH2:17][C:18]([OH:20])=[O:19])=[CH:14][CH:13]=1>C(#N)C>[Br-:10].[C:18]([CH2:17][O:16][C:15]1[CH:21]=[CH:22][C:12]([CH2:11][N:3]2[C:2]([Cl:1])=[C:6]([Cl:7])[N+:5]([CH2:11][C:12]3[CH:22]=[CH:21][C:15]([O:8][CH2:17][C:18]([OH:20])=[O:19])=[CH:14][CH:13]=3)=[CH:4]2)=[CH:13][CH:14]=1)([OH:20])=[O:19]

参加物

実験手順

4,5-dichloroimidazole (1.00 g, 7.36 mmol) was dissolved in acetonitrile. Potassium hydroxide (0.828 g, 14.72 mmol) was added to the solution and allowed to reflux for 30 min. 2 equivalents of 2-(4-(bromomethyl)phenoxy)acetic acid (3.61 g, 14.72 mmol) was added to the solution and refluxed for 5 h. Solution was filtered to remove the KBr precipitate and neutralized with 6M HBr. Volatiles were removed in vacuo and the resulting white precipitate was collected and analyzed. 1H NMR (300 MHz, DMSO-d6): δ 4.67, 5.51, 7.12, 7.61, 9.23, 12.17.